Combating Antibiotic Resistance Through the Health Impact Fund

Targets for Combating the Evolution of Acquired Antibiotic Resistance

Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics. Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves altering the target site of the drug, enzymatically inactivating the drug, or preventing the drug from accessing its target. These mechanisms involve new genetic changes in the pathogen leading to heritable resistance...

Inhibition of Mutation and Combating the Evolution of Antibiotic Resistance

The emergence of drug-resistant bacteria poses a serious threat to human health. In the case of several antibiotics, including those of the quinolone and rifamycin classes, bacteria rapidly acquire resistance through mutation of chromosomal genes during therapy. In this work, we show that preventing induction of the SOS response by interfering with the activity of the protease LexA renders path...

Bacterial SOS May Be the Key to Combating Antibiotic Resistance

Antibiotic resistance – the impact of intensive farming on human health

Scientists and leading figures are increasingly warning of a serious health crisis in future, where some infectious diseases will no longer be treatable, if we do not urgently start using antibiotics more sparingly and intelligently. Antibiotic resistance is developing faster than new antibiotics are being developed, as finding new antibiotics is becoming increasingly difficult and expensive.

Combating Antibiotic Resistance Through Development of a Novel Antimicrobial Delivery Vehicle